Which of the following statements about nuclear receptor signaling pathways are wrong?()

A．Nuclear receptors are a class of transcription regulators that regulate the transcription of specific proteins by hormones.
B．Nuclear receptors are distributed across the cell membrane
C．When the receptor binds to the ligand, it is usually transferred to the nucleus for its function
D．The occurrence of breast cancer, prostate cancer and other tumors is related to abnormal regulation of nuclear receptor signaling pathway